CLCA2 and ITGB4

Number of citations of the paper that reports this interaction (PubMedID 12110680)
39

Data Source:
HPRD (in vivo, in vitro)

		CLCA2	ITGB4
Description		chloride channel accessory 2	integrin subunit beta 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Junction Nuclear Membrane	Nucleolus Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Cell Junction Hemidesmosome Cell Leading Edge Nuclear Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Intracellular Calcium Activated Chloride Channel Activity Chloride Channel Activity Metallopeptidase Activity Ligand-gated Ion Channel Activity Metal Ion Binding	G Protein-coupled Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding
	Biological Process	Proteolysis Cell Adhesion Ion Transmembrane Transport Chloride Transmembrane Transport	Autophagy Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Cell Migration Extracellular Matrix Organization Hemidesmosome Assembly Cell Adhesion Mediated By Integrin Nail Development Skin Morphogenesis Mesodermal Cell Differentiation Cell Motility
Pathways		Stimuli-sensing channels	Assembly of collagen fibrils and other multimeric structures Laminin interactions Syndecan interactions Type I hemidesmosome assembly
Drugs			R1295
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Crohn's disease-related phenotypes ( 25557950)
Interacting Genes		1 interacting genes: ITGB4	25 interacting genes: ALOX12 ATXN1 CLCA1 CLCA2 COL17A1 DST EIF6 ERBB2 ERBIN FYN GRB2 ITGA6 MET PLEC PRKCA PRKCD PTK2 SDC2 SDC3 SHC1 SREBF2 VIM YES1 YWHAB YWHAQ
Entrez ID		9635	3691
HPRD ID		04923	00946
Ensembl ID		ENSG00000137975	ENSG00000132470
Uniprot IDs		Q9UQC9	A0A024R8K7 A0A024R8N2 A0A024R8T0 B7ZLD8 P16144
PDB IDs			1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A 4Q58 4WTW 4WTX 6GVK 6GVL
Enriched GO Terms of Interacting Partners?
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