ITGB4 and PLEC

Number of citations of the paper that reports this interaction (PubMedID 14668477)
40

Data Source:
HPRD (two hybrid, in vivo)

		ITGB4	PLEC
Description		integrin subunit beta 4	plectin
Image
GO Annotations	Cellular Component	Nucleolus Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Cell Junction Hemidesmosome Cell Leading Edge Nuclear Membrane Receptor Complex Extracellular Exosome	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Membrane Sarcoplasm Hemidesmosome Sarcolemma Costamere Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding	RNA Binding Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Ankyrin Binding Cadherin Binding
	Biological Process	Autophagy Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Cell Migration Extracellular Matrix Organization Hemidesmosome Assembly Cell Adhesion Mediated By Integrin Nail Development Skin Morphogenesis Mesodermal Cell Differentiation Cell Motility	Hemidesmosome Assembly Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Assembly of collagen fibrils and other multimeric structures Laminin interactions Syndecan interactions Type I hemidesmosome assembly	Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly
Drugs		R1295
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)
GWAS			Anti-saccade response ( 29064472) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Diastolic blood pressure ( 30224653) Fibrinogen levels ( 28107422 26561523) Height ( 31562340) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) Mean platelet volume ( 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)
Interacting Genes		25 interacting genes: ALOX12 ATXN1 CLCA1 CLCA2 COL17A1 DST EIF6 ERBB2 ERBIN FYN GRB2 ITGA6 MET PLEC PRKCA PRKCD PTK2 SDC2 SDC3 SHC1 SREBF2 VIM YES1 YWHAB YWHAQ	22 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 EGFR ITGA6 ITGB4 LMNB1 MAP2 MSN MTDH PLEKHA5 PTEN RACK1 SMAD9 SPTA1 SPTAN1 UBC VIM
Entrez ID		3691	5339
HPRD ID		00946	03180
Ensembl ID		ENSG00000132470	ENSG00000178209
Uniprot IDs		A0A024R8K7 A0A024R8N2 A0A024R8T0 B7ZLD8 P16144	Q15149
PDB IDs		1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A 4Q58 4WTW 4WTX 6GVK 6GVL	1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?