ITGB4 and ALOX12

Number of citations of the paper that reports this interaction (PubMedID 10727209)
12

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		ITGB4	ALOX12
Description		integrin subunit beta 4	arachidonate 12-lipoxygenase, 12S type
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GO Annotations	Cellular Component	Nucleolus Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Cell Junction Hemidesmosome Cell Leading Edge Nuclear Membrane Receptor Complex Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Sarcolemma Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding	Arachidonate 12-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hepoxilin-epoxide Hydrolase Activity Arachidonate 15-lipoxygenase Activity
	Biological Process	Autophagy Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Cell Migration Extracellular Matrix Organization Hemidesmosome Assembly Cell Adhesion Mediated By Integrin Nail Development Skin Morphogenesis Mesodermal Cell Differentiation Cell Motility	Lipid Metabolic Process Aging Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Arachidonic Acid Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Unsaturated Fatty Acid Metabolic Process Lipid Oxidation Superoxide Anion Generation Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Linoleic Acid Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Establishment Of Skin Barrier Cellular Response To Lipid Negative Regulation Of Platelet Aggregation Positive Regulation Of Blood Vessel Diameter Leukotriene A4 Metabolic Process Positive Regulation Of Endothelial Tube Morphogenesis Lipoxin Biosynthetic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process
Pathways		Assembly of collagen fibrils and other multimeric structures Laminin interactions Syndecan interactions Type I hemidesmosome assembly	Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Synthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Biosynthesis of DHA-derived SPMs Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived maresins
Drugs		R1295
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS			Blood metabolite levels ( 24816252)
Interacting Genes		25 interacting genes: ALOX12 ATXN1 CLCA1 CLCA2 COL17A1 DST EIF6 ERBB2 ERBIN FYN GRB2 ITGA6 MET PLEC PRKCA PRKCD PTK2 SDC2 SDC3 SHC1 SREBF2 VIM YES1 YWHAB YWHAQ	7 interacting genes: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1
Entrez ID		3691	239
HPRD ID		00946	01066
Ensembl ID		ENSG00000132470	ENSG00000108839
Uniprot IDs		A0A024R8K7 A0A024R8N2 A0A024R8T0 B7ZLD8 P16144	P18054
PDB IDs		1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A 4Q58 4WTW 4WTX 6GVK 6GVL	2ABU 3D3L
Enriched GO Terms of Interacting Partners?
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