ADAMTS4 and YTHDC1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ADAMTS4	YTHDC1
Description		ADAM metallopeptidase with thrombospondin type 1 motif 4	YTH domain containing 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Speck Collagen-containing Extracellular Matrix	Nucleus Nucleoplasm Plasma Membrane Nuclear Speck
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal Ion Binding	RNA Binding Protein Binding N6-methyladenosine-containing RNA Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly	MRNA Splice Site Selection MRNA Export From Nucleus Dosage Compensation By Inactivation Of X Chromosome Posttranscriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31361310 27182965 31619474) Family history of Alzheimer's disease ( 30617256) Monocyte percentage of white cells ( 27863252)	Obesity-related traits ( 23251661)
Interacting Genes		11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	35 interacting genes: ABL1 ADAMTS4 CFH CLK1 CLK2 CORO1A DVL3 EDC4 EMD FYN GOLGA2 HNRNPK KHDRBS1 KHDRBS2 KHDRBS3 KRT18 LAMC3 LAMTOR5 LZTS2 MPRIP PLG PROSER2 RBMY1F SDCBP2 SEPTIN10 SOX13 SRC SRPK1 SRPK2 SRSF1 SRSF2 TRA2A TRA2B TXK VPS51
Entrez ID		9507	91746
HPRD ID		04853	11689
Ensembl ID		ENSG00000158859	ENSG00000083896
Uniprot IDs		O75173	J3QR07 Q96MU7
PDB IDs		2RJP 3B2Z 4WK7 4WKE 4WKI	2YUD 4R3H 4R3I 6RT4 6RT5 6RT6 6RT7
Enriched GO Terms of Interacting Partners?
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