ADAMTS4 and HP

Number of citations of the paper that reports this interaction (PubMedID 16099106)
9

Data Source:
HPRD (two hybrid)

		ADAMTS4	HP
Description		ADAM metallopeptidase with thrombospondin type 1 motif 4	haptoglobin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Speck Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal Ion Binding	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly	Acute Inflammatory Response Proteolysis Receptor-mediated Endocytosis Defense Response Acute-phase Response Response To Organic Substance Positive Regulation Of Cell Death Response To Hydrogen Peroxide Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Scavenging of heme from plasma Neutrophil degranulation
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31361310 27182965 31619474) Family history of Alzheimer's disease ( 30617256) Monocyte percentage of white cells ( 27863252)	Blood protein levels ( 30072576 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010) Urinary haptoglobin levels in type 2 diabetes ( 29572449)
Interacting Genes		11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	21 interacting genes: ADAMTS4 APOA1 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		9507	3240
HPRD ID		04853	00772
Ensembl ID		ENSG00000158859	ENSG00000257017
Uniprot IDs		O75173	A0A0C4DGL8 P00738 Q6PEJ8
PDB IDs		2RJP 3B2Z 4WK7 4WKE 4WKI	4WJG 4X0L 5HU6
Enriched GO Terms of Interacting Partners?
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