ADAMTS4 and MT2A

Number of citations of the paper that reports this interaction (PubMedID 16099106)
9

Data Source:
HPRD (two hybrid)

		ADAMTS4	MT2A
Description		ADAM metallopeptidase with thrombospondin type 1 motif 4	metallothionein 2A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Speck Collagen-containing Extracellular Matrix	Cell Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal Ion Binding	Protein Binding Drug Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling
Drugs			Zinc
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31361310 27182965 31619474) Family history of Alzheimer's disease ( 30617256) Monocyte percentage of white cells ( 27863252)
Interacting Genes		11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	20 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 STOM TNS2 USP25
Entrez ID		9507	4502
HPRD ID		04853	08863
Ensembl ID		ENSG00000158859	ENSG00000125148
Uniprot IDs		O75173	P02795
PDB IDs		2RJP 3B2Z 4WK7 4WKE 4WKI	1MHU 2MHU
Enriched GO Terms of Interacting Partners?
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