MAGED1 and RNF6

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		MAGED1	RNF6
Description		MAGE family member D1	ring finger protein 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Plasma Membrane Protein-containing Complex	Nucleus Cytoplasm PML Body Axon Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coactivator Activity Protein Binding Identical Protein Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Androgen Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Axon Extension Protein K27-linked Ubiquitination Positive Regulation Of Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Sporadic pituitary adenoma ( 26029870) Type 2 diabetes ( 24509480 30297969 30718926 28869590) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		62 interacting genes: AKAP9 ARNT2 BAG3 BARD1 BHLHE40 BIRC8 BRCA2 C1orf94 CA8 CCDC33 DAB1 DAZAP2 DLX4 DLX5 EIF3J EIF4E2 EP300 GPR135 GRAP2 HGS HIVEP1 HNRNPLL KPNA2 KRTAP19-5 MAPK3 MDFI MEOX2 MPC1 MSX2 NGFR NOTCH1 NPAS4 NUMBL PITX1 PJA1 PJA2 PLK1 PRKAB2 PSMF1 RBFOX1 RBFOX2 RBM23 RBPMS RFX1 RHOXF2 RNF6 RNF8 ROR2 SIM2 SIRT7 SMAP2 SNRPC TFG TRAF4 TRIM28 TTC23 TTC32 TUBA4A UNC5A XIAP ZNF488 ZNF688	36 interacting genes: AHCYL1 AR CBY2 CCDC33 CCDC57 CEP70 GOLGA2 HOOK2 IKZF1 IKZF3 KIAA0753 KRT15 KRT40 LDOC1 MAGED1 MDFI MEOX2 MID2 MIPOL1 MTUS2 PNMA2 REL RINT1 RPGRIP1 SSX2IP STX11 TADA2A TCF4 TFIP11 TNS2 TRIM23 TRIM27 TRIM37 TSGA10 UBE2D1 UBE2H
Entrez ID		9500	6049
HPRD ID		02202	05027
Ensembl ID		ENSG00000179222	ENSG00000127870
Uniprot IDs		Q9Y5V3	A0A024RDP2 A0A0S2Z4G9 Q9Y252
PDB IDs
Enriched GO Terms of Interacting Partners?
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