MAGED1 and AKAP9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MAGED1	AKAP9
Description		MAGE family member D1	A-kinase anchoring protein 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Plasma Membrane Protein-containing Complex	Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Identical Protein Binding	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Postsynaptic Neurotransmitter Receptor Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Golgi Organization
Pathways		NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2
Drugs
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS			Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		62 interacting genes: AKAP9 ARNT2 BAG3 BARD1 BHLHE40 BIRC8 BRCA2 C1orf94 CA8 CCDC33 DAB1 DAZAP2 DLX4 DLX5 EIF3J EIF4E2 EP300 GPR135 GRAP2 HGS HIVEP1 HNRNPLL KPNA2 KRTAP19-5 MAPK3 MDFI MEOX2 MPC1 MSX2 NGFR NOTCH1 NPAS4 NUMBL PITX1 PJA1 PJA2 PLK1 PRKAB2 PSMF1 RBFOX1 RBFOX2 RBM23 RBPMS RFX1 RHOXF2 RNF6 RNF8 ROR2 SIM2 SIRT7 SMAP2 SNRPC TFG TRAF4 TRIM28 TTC23 TTC32 TUBA4A UNC5A XIAP ZNF488 ZNF688	67 interacting genes: ASB4 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 DVL2 FMR1 FNBP1 FXR2 GATAD1 GPC4 GRIN1 GTSE1 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 SAMD3 SF3B2 SGCE SLAIN1 SSX2 SUV39H2 TACC3 TDP2 THAP1 TNIK TRIP10 TSG101 TSNAX TUBGCP3 USHBP1 USO1 WAC YWHAE
Entrez ID		9500	10142
HPRD ID		02202	04921
Ensembl ID		ENSG00000179222	ENSG00000127914
Uniprot IDs		Q9Y5V3	Q5GIA7 Q6PJH3 Q99996
PDB IDs
Enriched GO Terms of Interacting Partners?
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