RNF6 and TNS2

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		RNF6	TNS2
Description		ring finger protein 6	tensin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm PML Body Axon Nuclear Membrane Intracellular Membrane-bounded Organelle	Cell Plasma Membrane Focal Adhesion
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Androgen Receptor Binding Ubiquitin Protein Ligase Activity	Protein Tyrosine Phosphatase Activity Protein Binding Kinase Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Axon Extension Protein K27-linked Ubiquitination Positive Regulation Of Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination	Kidney Development Negative Regulation Of Cell Proliferation Response To Muscle Activity Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Negative Regulation Of Insulin Receptor Signaling Pathway Multicellular Organismal Homeostasis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Sporadic pituitary adenoma ( 26029870) Type 2 diabetes ( 24509480 30297969 30718926 28869590) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		36 interacting genes: AHCYL1 AR CBY2 CCDC33 CCDC57 CEP70 GOLGA2 HOOK2 IKZF1 IKZF3 KIAA0753 KRT15 KRT40 LDOC1 MAGED1 MDFI MEOX2 MID2 MIPOL1 MTUS2 PNMA2 REL RINT1 RPGRIP1 SSX2IP STX11 TADA2A TCF4 TFIP11 TNS2 TRIM23 TRIM27 TRIM37 TSGA10 UBE2D1 UBE2H	86 interacting genes: ADCK5 AMMECR1 AP1S2 ASB3 AXL BRCA1 C11orf87 COX6B2 CSNK1E DCAF11 DCAF8 DDIT4L DLC1 DOK3 EPB41L4A EPS8L2 ERBB2 ERBB3 FABP7 FAM114A1 FGF21 FGFR1 FOXO1 GATA1 GBA3 GFI1B HUWE1 ID2 IHO1 ITGB3 ITGB5 ITGB7 KIF1A KPRP KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP13-1 KRTAP23-1 KRTAP3-1 MPEG1 MT2A MTDH MYBPHL MYH7B NMU NT5C NUBP2 OBSL1 OTX1 PER1 PKP1 PLB1 PLK3 POLR3F RBPMS REEP6 REL RFT1 RNF6 SDCCAG8 SH2B3 SHFL SPATA12 SPRY2 SPRY4 SUV39H1 TBC1D16 TCP10L TEKT5 TENT5A TLE5 TM4SF19 TSC1 TWSG1 WDFY3 ZNF250 ZNF417 ZNF586 ZNF587 ZNF655 ZNF688 ZNRD1
Entrez ID		6049	23371
HPRD ID		05027	16256
Ensembl ID		ENSG00000127870	ENSG00000111077
Uniprot IDs		A0A024RDP2 A0A0S2Z4G9 Q9Y252	A0A024RB48 Q63HR2
PDB IDs			2DKQ 2KNO 2L6K 2LOZ 3HQC
Enriched GO Terms of Interacting Partners?
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