RNF6 and AHCYL1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		RNF6	AHCYL1
Description		ring finger protein 6	adenosylhomocysteinase like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm PML Body Axon Nuclear Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Apical Plasma Membrane Extracellular Exosome
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Androgen Receptor Binding Ubiquitin Protein Ligase Activity	RNA Binding Adenosylhomocysteinase Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Axon Extension Protein K27-linked Ubiquitination Positive Regulation Of Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination	MRNA Polyadenylation Protein Export From Nucleus One-carbon Metabolic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Anion Transport Response To Calcium Ion Regulation Of Cardiac Conduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Sporadic pituitary adenoma ( 26029870) Type 2 diabetes ( 24509480 30297969 30718926 28869590) Urate levels (BMI interaction) ( 25811787)	Height ( 31562340)
Interacting Genes		36 interacting genes: AHCYL1 AR CBY2 CCDC33 CCDC57 CEP70 GOLGA2 HOOK2 IKZF1 IKZF3 KIAA0753 KRT15 KRT40 LDOC1 MAGED1 MDFI MEOX2 MID2 MIPOL1 MTUS2 PNMA2 REL RINT1 RPGRIP1 SSX2IP STX11 TADA2A TCF4 TFIP11 TNS2 TRIM23 TRIM27 TRIM37 TSGA10 UBE2D1 UBE2H	17 interacting genes: BID CDKN2C DACH1 GEM HGS ITPR1 LRRK2 MEOX2 MFHAS1 PPL PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 ZNF165
Entrez ID		6049	10768
HPRD ID		05027	07613
Ensembl ID		ENSG00000127870	ENSG00000168710
Uniprot IDs		A0A024RDP2 A0A0S2Z4G9 Q9Y252	A0A024R0A8 O43865
PDB IDs			3MTG
Enriched GO Terms of Interacting Partners?
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