GAREM1 and GRAP2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		GAREM1	GRAP2
Description		GRB2 associated regulator of MAPK1 subtype 1	GRB2 related adaptor protein 2
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GO Annotations	Cellular Component	Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane
	Molecular Function	Protein Binding Proline-rich Region Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Left ventricular internal dimension in diastole ( 29403010) Left ventricular internal dimension in systole ( 29403010)	Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)
Interacting Genes		4 interacting genes: CRK CRKL GRAP2 GRB2	66 interacting genes: BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MTUS2 PNMA1 PRPH2 RACK1 RBPMS RBX1 RIN3 RINT1 SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF526
Entrez ID		64762	9402
HPRD ID		12685	05156
Ensembl ID		ENSG00000141441	ENSG00000100351
Uniprot IDs		Q9H706	B7Z8E3 O75791 Q6FI14
PDB IDs		2DKZ	5GJH
Enriched GO Terms of Interacting Partners?
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