LAX1 and GRAP2

Number of citations of the paper that reports this interaction (PubMedID 12359715)
30

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		LAX1	GRAP2
Description		lymphocyte transmembrane adaptor 1	GRB2 related adaptor protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Membrane Integral Component Of Membrane Membrane Raft	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane
	Molecular Function	Protein Binding Protein Kinase Binding SH2 Domain Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Inactivation Of MAPK Activity Adaptive Immune Response Immune Response Intracellular Signal Transduction B Cell Activation Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Activation	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072)	Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)
Interacting Genes		9 interacting genes: GRAP2 GRB2 GRB7 IDH1 LCK NDN STAMBPL1 SYK ZAP70	66 interacting genes: BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MTUS2 PNMA1 PRPH2 RACK1 RBPMS RBX1 RIN3 RINT1 SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF526
Entrez ID		54900	9402
HPRD ID		08312	05156
Ensembl ID		ENSG00000122188	ENSG00000100351
Uniprot IDs		Q8IWV1	B7Z8E3 O75791 Q6FI14
PDB IDs			5GJH
Enriched GO Terms of Interacting Partners?
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