CSF1R and STAP2

Number of citations of the paper that reports this interaction (PubMedID 17512498)
2

Data Source:
BioGRID (pull down)

		CSF1R	STAP2
Description		colony stimulating factor 1 receptor	signal transducing adaptor family member 2
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Intracellular Membrane-bounded Organelle Receptor Complex CSF1-CSF1R Complex	Cytosol Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding Cytokine Binding Protein Homodimerization Activity	Protein Binding Signaling Adaptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Hematopoietic Progenitor Cell Differentiation Response To Ischemia Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Olfactory Bulb Development Forebrain Neuron Differentiation Hemopoiesis Monocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Positive Regulation Of Cell Migration Ruffle Organization Positive Regulation Of Kinase Activity Cellular Response To Macrophage Colony-stimulating Factor Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Process Innate Immune Response Regulation Of Bone Resorption Cell-cell Junction Maintenance Phosphatidylinositol Metabolic Process Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Mammary Gland Duct Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Microglial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Chemokine Secretion Positive Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization	Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Pathways		Other interleukin signaling Transcriptional Regulation by VENTX	PTK6 Activates STAT3
Drugs		Imatinib Sunitinib ABT-869 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE
Diseases		Choriocarcinoma
GWAS		Blood protein levels ( 30072576 28240269) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252)	Tea consumption ( 31046077)
Interacting Genes		23 interacting genes: CBL CSF1 CTDSP1 CTDSP2 FYN GRAP2 GRB2 INPP5D INPPL1 KIT LAMC2 LYN PIK3CA PIK3R1 PIK3R2 RASA1 SHC1 SOCS1 SOCS3 SOS1 STAP2 THOC5 YES1	14 interacting genes: BMP4 CBL CHUK CSF1R EGFR IKBKB JAK2 MLH1 MYD88 PTK6 SRC STAT3 STAT5A STAT5B
Entrez ID		1436	55620
HPRD ID		01269	07430
Ensembl ID		ENSG00000182578	ENSG00000178078
Uniprot IDs		P07333	Q9UGK3
PDB IDs		2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7 4LIQ 4R7H 4R7I 4WRL 4WRM 6IG8 6N33	2EL8
Enriched GO Terms of Interacting Partners?
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