CNOT8 and BTG2

Number of citations of the paper that reports this interaction (PubMedID 11136725)
39

Data Source:
HPRD (in vivo, in vitro)

		CNOT8	BTG2
Description		CCR4-NOT transcription complex subunit 8	BTG anti-proliferation factor 2
Image		No pdb structure
GO Annotations	Cellular Component	P-body Intracellular Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity DNA-binding Transcription Factor Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding	DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Translation Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Protein Methylation Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Cell Proliferation Associative Learning Response To Mechanical Stimulus Anterior/posterior Pattern Specification Response To Organic Cyclic Compound Negative Regulation Of Translation Dentate Gyrus Development Central Nervous System Neuron Development Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Response To Electrical Stimulus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS			Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 27863252 28957414)
Interacting Genes		9 interacting genes: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2	11 interacting genes: CNOT7 CNOT8 HOXB9 HOXC8 PICK1 PRKCA PRMT1 SKP2 SMAD1 SMAD9 SRA1
Entrez ID		9337	7832
HPRD ID		07225	03357
Ensembl ID		ENSG00000155508	ENSG00000159388
Uniprot IDs		B7Z9U0 Q9UFF9	P78543
PDB IDs			3DJU 3E9V
Enriched GO Terms of Interacting Partners?
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