CNOT8 and CNOT6

Number of citations of the paper that reports this interaction (PubMedID 10637334)
63

Data Source:
HPRD (two hybrid)

		CNOT8	CNOT6
Description		CCR4-NOT transcription complex subunit 8	CCR4-NOT transcription complex subunit 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Intracellular Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex
	Molecular Function	3'-5'-exoribonuclease Activity DNA-binding Transcription Factor Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Translation Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Proliferation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, No-go Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear Receptor Transcription Coactivator Activity
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS			Ovarian cancer ( 30557369)
Interacting Genes		9 interacting genes: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2	4 interacting genes: CNOT4 CNOT7 CNOT8 PABPC1
Entrez ID		9337	57472
HPRD ID		07225	12341
Ensembl ID		ENSG00000155508	ENSG00000113300
Uniprot IDs		B7Z9U0 Q9UFF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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