CNOT8 and TOB2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CNOT8	TOB2
Description		CCR4-NOT transcription complex subunit 8	transducer of ERBB2, 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Intracellular Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	3'-5'-exoribonuclease Activity DNA-binding Transcription Factor Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding	Transcription Corepressor Activity Protein Binding Vitamin D Receptor Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Translation Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Female Gamete Generation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Ossification Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Autism spectrum disorder or schizophrenia ( 28540026) Neuroticism ( 29255261) Vitiligo ( 22561518)
Interacting Genes		9 interacting genes: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2	5 interacting genes: BHLHE40 CEP76 CNOT7 CNOT8 RPS6KA1
Entrez ID		9337	10766
HPRD ID		07225	09583
Ensembl ID		ENSG00000155508	ENSG00000183864
Uniprot IDs		B7Z9U0 Q9UFF9	Q14106
PDB IDs
Enriched GO Terms of Interacting Partners?
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