LONRF1 and UCHL3

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		LONRF1	UCHL3
Description		LON peptidase N-terminal domain and ring finger 1	ubiquitin C-terminal hydrolase L3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Metal Ion Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity NEDD8-specific Protease Activity Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding
	Biological Process	Protein Polyubiquitination	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Catabolic Process Post-translational Protein Modification
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation
Drugs
Diseases
GWAS		Colorectal cancer (diet interaction) ( 24743840)	Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)
Interacting Genes		33 interacting genes: ADAMTSL4 ALAS1 ATG9A BRCA1 BYSL CALCOCO2 CRX EFHC2 GORASP1 GORASP2 HSPB1 IHO1 IKZF2 IQCF2 KAT5 KCTD9 KRT31 KRTAP13-1 LHX4 NR4A1 NTAQ1 PLSCR1 RBPMS SFN SPRY2 STAU1 STX11 TRIM42 TRIM9 UBE2L6 UCHL3 USP2 XIAP	19 interacting genes: ATM ATXN7L3 CDH1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5
Entrez ID		91694	7347
HPRD ID		08674	04367
Ensembl ID		ENSG00000154359	ENSG00000118939
Uniprot IDs		Q17RB8	A0A087WTB8 A0A140VJZ4 P15374
PDB IDs			1UCH 1XD3 6ISU
Enriched GO Terms of Interacting Partners?
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