RABEP1 and RABGEF1

Number of citations of the paper that reports this interaction (PubMedID 12505986)
55

Data Source:
HPRD (in vitro)

		RABEP1	RABGEF1
Description		rabaptin, RAB GTPase binding effector protein 1	RAB guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Endosome Early Endosome Endocytic Vesicle Early Endosome Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Recycling Endosome	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome
	Molecular Function	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Domain Specific Binding Protein Homodimerization Activity	DNA Binding Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Golgi To Plasma Membrane Transport Endocytosis Apoptotic Process Signal Transduction Protein Transport Vesicle-mediated Transport Positive Regulation Of GTPase Activity Membrane Fusion Protein Localization To Ciliary Membrane	Protein Targeting To Membrane Endocytosis
Pathways		TBC/RABGAPs	TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Body mass index ( 28892062 25673413) Red blood cell density in sickle cell anemia ( 28552477) White blood cell count ( 27863252)	Aortic root size ( 21223598) Central corneal thickness ( 29760442)
Interacting Genes		24 interacting genes: AP1G1 AP1G2 ATXN7 CASP3 CCND1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 ITSN2 RAB1A RAB33B RAB4A RAB5A RABGEF1 RGS17 SMURF1 SRPK2 TRIM26 TSC2 UBC YWHAG	29 interacting genes: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 DNAJC5 GGA1 GGA2 HRAS KXD1 MON1A MON1B RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C
Entrez ID		9135	27342
HPRD ID		04684	11477
Ensembl ID		ENSG00000029725	ENSG00000154710
Uniprot IDs		B4DMM4 Q15276	A0A024RDL6 A0A0A0MSJ3 A8K3R3 B3KMF1 Q9UJ41
PDB IDs		1P4U 1TU3 1X79 4N3Y 4N3Z 4Q9U	1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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