LATS1 and CBY2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LATS1	CBY2
Description		large tumor suppressor kinase 1	chibby family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Cytoplasmic Vesicle
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS		Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Testicular germ cell tumor ( 28604728)
Interacting Genes		45 interacting genes: ALPP APP AURKB CAV1 CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NF2 NUAK1 NUAK2 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 UBE2I WWOX WWP1 WWTR1 ZYX	76 interacting genes: ACTN1 ARHGEF40 ARMC7 C19orf44 C1orf109 CCDC146 CCDC198 CCHCR1 CCNG1 CDC23 CDK2 CEP44 CEP57L1 CEP95 CHCHD3 CHIC2 CKS1B CNNM3 DGCR6 DUSP14 DZIP1L EIF4E2 ELOA ENKD1 FAM161A FANCG FRS3 GADD45A GOLGA2 GOLGA6L2 GRAP2 HAUS1 KIFC3 KLC3 LATS1 LENG1 LMO1 LMO2 LMO3 LNX1 MED28 METTL17 MLH1 MMAB MOS NDUFA5 NINL NTAQ1 PID1 PIN1 PLEKHN1 POLR1C PPP1R18 PRPF31 RNF6 RPL9 RTP5 RUNX1T1 SCNM1 SDCBP SH3RF2 SYCE1 TCEANC TEX11 TRIM42 TSC2 TSGA10 TUBGCP4 TXLNA TXLNB ZC2HC1C ZMAT2 ZNF564 ZNF581 ZNF655 ZNF688
Entrez ID		9113	220082
HPRD ID		09147	14856
Ensembl ID		ENSG00000131023	ENSG00000174015
Uniprot IDs		O95835	A0A140VJV5 Q8NA61
PDB IDs		4ZRK 5B5W 5BRK
Enriched GO Terms of Interacting Partners?
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