LATS1 and KRT31

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LATS1	KRT31
Description		large tumor suppressor kinase 1	keratin 31
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Extracellular Space Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process	Cytoskeleton Organization Epidermis Development Keratinization Cornification
Pathways		Signaling by Hippo	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Testicular germ cell tumor ( 28604728)	Brown vs. black hair color ( 30531825)
Interacting Genes		45 interacting genes: ALPP APP AURKB CAV1 CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NF2 NUAK1 NUAK2 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 UBE2I WWOX WWP1 WWTR1 ZYX	184 interacting genes: ABI2 AGR2 ALDH3B1 AMOT AMOTL2 ANKRD36BP1 AQP1 AQP5 ARHGAP35 ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 BEX2 BTC BYSL C12orf49 C19orf73 C1orf109 C1orf216 C2CD6 C5orf60 CA6 CARD9 CATIP CCDC112 CCDC120 CCDC17 CCDC196 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK18 CDKN1A CEP57 CEP57L1 CEP70 CFAP206 CHCHD2 CHRNG CLDN2 COA5 COMT COX5A COX5B CRH CTSG DGCR6L DHX37 DMRT3 DTNB EIF4E2 EXOC8 FAM110A FAM124B FAM71C FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FKBP1B FOXB1 GAD1 GEM GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GPS2 GSTP1 HAUS1 HDAC4 HGS HNRNPLL HOXA1 HSPA12B HSPD1 ICAM4 INPP5D INPP5K INSR JOSD1 KIFC3 KLC1 KLC4 KLHL38 KRT2 KRT5 KRT6A KRT6B KRT6C KRT71 KRT77 KRT79 KRT8 KRT81 KRT83 LATS1 LCE4A LENG1 LIN37 LINC00526 LMF2 LMO4 LONRF1 MAP3K7CL MAPKBP1 MARK4 MRPL40 NAV1 NAXD NEK6 NPBWR2 NTAQ1 OTUB2 P2RX7 PDE4DIP PGLS PIN1 PKN1 PPP1R18 PRF1 PRKAA2 PRR19 PSMA1 PSMG2 PSPC1 PTGER3 PTPMT1 RADIL RAMAC RCOR3 RIBC1 RPUSD3 RSPH14 SCNM1 SEMA4C SHC3 SIRPA SLC15A3 SLC23A1 SLC25A6 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SPATA24 SPON2 SRSF2 SSX2IP TAPBPL THAP7 TLE5 TMEM106C TMEM231 TMSB4X TRAF4 TROAP TSG101 TTC23 TXLNA USHBP1 UTP23 UXT WDR25 ZFYVE21 ZNF124 ZNF148 ZNF20 ZNF569 ZNF572 ZNF688 ZNF69 ZNRF2P1
Entrez ID		9113	3881
HPRD ID		09147	03047
Ensembl ID		ENSG00000131023	ENSG00000094796
Uniprot IDs		O95835	Q15323
PDB IDs		4ZRK 5B5W 5BRK
Enriched GO Terms of Interacting Partners?
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