WASF1 and PSTPIP1

Number of citations of the paper that reports this interaction (PubMedID 9804817)
21

Data Source:
HPRD (in vitro, in vivo)

		WASF1	PSTPIP1
Description		WASP family member 1	proline-serine-threonine phosphatase interacting protein 1
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Postsynapse	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Rac GTPase Binding Protein Kinase A Binding	Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Receptor-mediated Endocytosis Rac Protein Signal Transduction Actin Filament Polymerization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS			Neurofibrillary tangles ( 31497858)
Interacting Genes		31 interacting genes: ABI1 ABL1 ACTB ACTG1 ACTR2 ACTR3 BAD BAIAP2 BRK1 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP FYN GNAI1 GRB2 IFT20 IL12A MAPKAPK2 NCK1 NCKAP1 NYAP2 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRIP10	42 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 DNM2 EXOC5 FAM90A1 FASLG FBXL18 HMG20A KHDRBS1 LSM4 MEFV MFGE8 MVP NAV2 PCDHB14 PRPF31 PTPN12 PTPN18 RINT1 RTP5 RXRB SDCBP SH2D4A SHBG SPG7 SYCE1 TFIP11 TRAF3IP3 TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175 ZNF688
Entrez ID		8936	9051
HPRD ID		05434	05891
Ensembl ID		ENSG00000112290	ENSG00000140368
Uniprot IDs		Q92558	A0A0S2Z5P3 O43586
PDB IDs		3P8C 4N78	2DIL
Enriched GO Terms of Interacting Partners?
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