PSTPIP1 and PTPN12

Number of citations of the paper that reports this interaction (PubMedID 11971877)
79

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro, in vivo)

		PSTPIP1	PTPN12
Description		proline-serine-threonine phosphatase interacting protein 1	protein tyrosine phosphatase non-receptor type 12
Image
GO Annotations	Cellular Component	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Cytokine Stimulus Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs
Diseases		Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Neurofibrillary tangles ( 31497858)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		42 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 DNM2 EXOC5 FAM90A1 FASLG FBXL18 HMG20A KHDRBS1 LSM4 MEFV MFGE8 MVP NAV2 PCDHB14 PRPF31 PTPN12 PTPN18 RINT1 RTP5 RXRB SDCBP SH2D4A SHBG SPG7 SYCE1 TFIP11 TRAF3IP3 TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175 ZNF688	48 interacting genes: AATK ABL1 APP BAG6 BCAR1 CGA CSH1 CSH2 CSK EFS EGFR EIF4H ERBB3 ERBB4 FGFR2 FGFR4 FLT3 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SHC1 SMAD5 SORBS2 STX16 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2
Entrez ID		9051	5782
HPRD ID		05891	02513
Ensembl ID		ENSG00000140368	ENSG00000127947
Uniprot IDs		A0A0S2Z5P3 O43586	B4E105 Q05209
PDB IDs		2DIL	5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?
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