WASF1 and IL12A

Number of citations of the paper that reports this interaction (PubMedID 16862120)
134

Data Source:
HPRD (in vitro)

		WASF1	IL12A
Description		WASP family member 1	interleukin 12A
Image
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Postsynapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cell Surface Late Endosome Lumen Interleukin-12 Complex
	Molecular Function	Actin Binding Protein Binding Rac GTPase Binding Protein Kinase A Binding	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity
	Biological Process	Receptor-mediated Endocytosis Rac Protein Signal Transduction Actin Filament Polymerization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Cell Cycle Arrest Cell Proliferation Response To Virus Response To UV-B Viral Process Cell Migration Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process T-helper 1 Cell Activation Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Cytokine Production Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Protozoan Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Interleukin-35-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling
Drugs
Diseases
GWAS			Behcet's disease ( 23291587 27548383 25799145) Bipolar disorder ( 31043756) Celiac disease ( 22057235 20190752 25920553 18311140) Limited cutaneous systemic scleroderma ( 24387989) Major depressive disorder ( 23377640) Multiple sclerosis ( 24076602 19525953 21833088) Primary biliary cholangitis ( 28425483 19458352 21399635 20639880 26394269 28062665) Primary biliary cirrhosis ( 22961000) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic sclerosis ( 24387989 31672989)
Interacting Genes		31 interacting genes: ABI1 ABL1 ACTB ACTG1 ACTR2 ACTR3 BAD BAIAP2 BRK1 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP FYN GNAI1 GRB2 IFT20 IL12A MAPKAPK2 NCK1 NCKAP1 NYAP2 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRIP10	5 interacting genes: CD28 CXCL8 EBI3 IL12B WASF1
Entrez ID		8936	3592
HPRD ID		05434	01193
Ensembl ID		ENSG00000112290	ENSG00000168811
Uniprot IDs		Q92558	O60595 P29459
PDB IDs		3P8C 4N78	1F45 3HMX
Enriched GO Terms of Interacting Partners?
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