IQGAP1 and VASP

Number of citations of the paper that reports this interaction (PubMedID 21451103)
9

Data Source:
BioGRID (pull down)

		IQGAP1	VASP
Description		IQ motif containing GTPase activating protein 1	vasodilator stimulated phosphoprotein
Image
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Lateral Plasma Membrane Axon Growth Cone Midbody Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Membrane Raft Extracellular Exosome Ribonucleoprotein Complex	Cytosol Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Exosome
	Molecular Function	GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Protein-containing Complex Binding Cadherin Binding Rac GTPase Binding Mitogen-activated Protein Kinase Binding Molecular Adaptor Activity	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding
	Biological Process	Regulation Of Cytokine Production Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Viral Process Cell Migration Negative Regulation Of GTPase Activity Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Glomerular Visceral Epithelial Cell Development Positive Regulation Of Dendrite Development Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Localization Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Neuron Projection Extension Response To Angiotensin	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Cell Junction Assembly Protein Homotetramerization
Pathways		Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs		Artenimol
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Heel bone mineral density ( 30598549) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) White blood cell count (basophil) ( 27863252)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
Interacting Genes		29 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CTNNB1 CYBB EGFR EZR GRIA4 KDR MAPK1 MEN1 MYL1 NPHS1 PDLIM7 PRKACA PTPRM RAC1 S100B STAU1 TSG101 UBE2I VASP YWHAQ	42 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP CEP43 DMRTB1 DNMBP ENAH ERMAP EVL FAT1 FRS3 FYB1 GSN IQGAP1 LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A RAD51 RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX
Entrez ID		8826	7408
HPRD ID		04541	03415
Ensembl ID		ENSG00000140575	ENSG00000125753
Uniprot IDs		A0A024RC65 P46940	A0A024R0V4 P50552
PDB IDs		1X0H 2RR8 3FAY 3I6X 5L0O	1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?
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