IQGAP1 and AIMP1

Number of citations of the paper that reports this interaction (PubMedID 22863883)
93

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		IQGAP1	AIMP1
Description		IQ motif containing GTPase activating protein 1	aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Image
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Lateral Plasma Membrane Axon Growth Cone Midbody Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Membrane Raft Extracellular Exosome Ribonucleoprotein Complex	Extracellular Space Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Cell Surface Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Protein-containing Complex Binding Cadherin Binding Rac GTPase Binding Mitogen-activated Protein Kinase Binding Molecular Adaptor Activity	TRNA Binding Cytokine Activity Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Regulation Of Cytokine Production Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Viral Process Cell Migration Negative Regulation Of GTPase Activity Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Glomerular Visceral Epithelial Cell Development Positive Regulation Of Dendrite Development Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Localization Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Neuron Projection Extension Response To Angiotensin	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation TRNA Aminoacylation For Protein Translation Apoptotic Process Chemotaxis Inflammatory Response Signal Transduction Cell-cell Signaling Response To Wounding Leukocyte Migration Defense Response To Virus Positive Regulation Of Glucagon Secretion
Pathways		Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Selenoamino acid metabolism Cytosolic tRNA aminoacylation
Drugs		Artenimol
Diseases			Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Heel bone mineral density ( 30598549) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) White blood cell count (basophil) ( 27863252)
Interacting Genes		29 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CTNNB1 CYBB EGFR EZR GRIA4 KDR MAPK1 MEN1 MYL1 NPHS1 PDLIM7 PRKACA PTPRM RAC1 S100B STAU1 TSG101 UBE2I VASP YWHAQ	8 interacting genes: AIMP2 APP ATP5F1A IQGAP1 MAPK14 MAPK8 RARS1 TSNAX
Entrez ID		8826	9255
HPRD ID		04541	04676
Ensembl ID		ENSG00000140575	ENSG00000164022
Uniprot IDs		A0A024RC65 P46940	B4DNK3 Q12904
PDB IDs		1X0H 2RR8 3FAY 3I6X 5L0O	1E7Z 1EUJ 1FL0 4R3Z
Enriched GO Terms of Interacting Partners?
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