IQGAP1 and GRIA4

Number of citations of the paper that reports this interaction (PubMedID 16190873)
16

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		IQGAP1	GRIA4
Description		IQ motif containing GTPase activating protein 1	glutamate ionotropic receptor AMPA type subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Lateral Plasma Membrane Axon Growth Cone Midbody Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Membrane Raft Extracellular Exosome Ribonucleoprotein Complex	Plasma Membrane Cell Junction Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Postsynaptic Density Membrane Extracellular Vesicle
	Molecular Function	GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Protein-containing Complex Binding Cadherin Binding Rac GTPase Binding Mitogen-activated Protein Kinase Binding Molecular Adaptor Activity	Amyloid-beta Binding Ionotropic Glutamate Receptor Activity AMPA Glutamate Receptor Activity Glutamate Receptor Activity Ligand-gated Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Regulation Of Cytokine Production Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Viral Process Cell Migration Negative Regulation Of GTPase Activity Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Glomerular Visceral Epithelial Cell Development Positive Regulation Of Dendrite Development Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Localization Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Neuron Projection Extension Response To Angiotensin	Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Regulation Of NMDA Receptor Activity
Pathways		Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules
Drugs		Artenimol	Glutamic Acid Ethanol Talampanel CX717 Fluciclovine (18F)
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Heel bone mineral density ( 30598549) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) White blood cell count (basophil) ( 27863252)	Age at first sexual intercourse ( 27089180) Myopia ( 27182965) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1 ( 26634245) Refractive error ( 23396134) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		29 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CTNNB1 CYBB EGFR EZR GRIA4 KDR MAPK1 MEN1 MYL1 NPHS1 PDLIM7 PRKACA PTPRM RAC1 S100B STAU1 TSG101 UBE2I VASP YWHAQ	12 interacting genes: ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP
Entrez ID		8826	2893
HPRD ID		04541	00694
Ensembl ID		ENSG00000140575	ENSG00000152578
Uniprot IDs		A0A024RC65 P46940	P48058 Q1WWK6
PDB IDs		1X0H 2RR8 3FAY 3I6X 5L0O
Enriched GO Terms of Interacting Partners?
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