VASP and LPP

Number of citations of the paper that reports this interaction (PubMedID 10637295)
46

Data Source:
HPRD (in vitro, in vivo)

		VASP	LPP
Description		vasodilator stimulated phosphoprotein	LIM domain containing preferred translocation partner in lipoma
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Exosome	Stress Fiber Nucleus Cytosol Plasma Membrane Focal Adhesion
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding	Protein Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Cell Junction Assembly Protein Homotetramerization	Biological_process Cell-cell Adhesion
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 31361310 30929738 27182965 31619474) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) B cell non-Hodgkin lymphoma ( 23749188) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 27539887) Blood protein levels ( 29875488) Celiac disease ( 22057235 20190752 18311140) Chronic kidney disease ( 29124443) Chronic lymphocytic leukemia ( 28165464 26956414) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Cutaneous squamous cell carcinoma ( 27424798) Early spontaneous preterm birth ( 31477735) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Estimated glomerular filtration rate ( 29124443) Follicular lymphoma ( 25279986) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Graves' disease ( 22922229) Hodgkin's lymphoma ( 29196614) IgE levels ( 22075330) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 29785010 31959993 29235454) Itch intensity from mosquito bite ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 27863252) Mortality in sepsis ( 27639821) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Nodular sclerosis Hodgkin lymphoma ( 29196614) Obesity-related traits ( 23251661) Renal function-related traits (BUN) ( 22797727) Response to platinum-based chemotherapy (cisplatin) ( 21844884) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966) Type 2 diabetes ( 24509480 30054458 30297969 25760438 28869590) Type 2 diabetes (young onset) and obesity ( 24465431) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 22951725 20410501 27723757) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		42 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP CEP43 DMRTB1 DNMBP ENAH ERMAP EVL FAT1 FRS3 FYB1 GSN IQGAP1 LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A RAD51 RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX	8 interacting genes: ACTN1 AP2M1 ATP5MF ATRAID MTNR1A SCRIB SHPRH VASP
Entrez ID		7408	4026
HPRD ID		03415	02828
Ensembl ID		ENSG00000125753	ENSG00000145012
Uniprot IDs		A0A024R0V4 P50552	B7Z871 B7Z8W0 B7ZLW0 Q93052
PDB IDs		1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?
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