SCIN and ACTC1

Number of citations of the paper that reports this interaction (PubMedID 12438125)
4

Data Source:
HPRD (in vivo)

		SCIN	ACTC1
Description		scinderin	actin alpha cardiac muscle 1
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Cell Cytoplasm Plasma Membrane Brush Border Cell Cortex Cell Junction Protein-containing Complex Cell Projection Extracellular Exosome	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Actomyosin, Actin Portion Cell Body Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	Phosphatidylserine Binding Actin Binding Calcium Ion Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Negative Regulation Of Cell Proliferation Calcium Ion Regulated Exocytosis Regulation Of Chondrocyte Differentiation Sequestering Of Actin Monomers Positive Regulation Of Apoptotic Process Actin Nucleation Positive Regulation Of Megakaryocyte Differentiation Actin Filament Severing Positive Regulation Of Secretion Positive Regulation Of Actin Nucleation Actin Filament Capping	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration
Pathways			Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)
GWAS		Height ( 31562340) Metabolite levels ( 23823483) Small cell lung carcinoma ( 28604730)	Axial length ( 24144296) Refractive error ( 20835239)
Interacting Genes		4 interacting genes: ACTA1 ACTC1 ACTG1 UBAP2L	39 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		85477	70
HPRD ID		11539	00015
Ensembl ID		ENSG00000006747	ENSG00000159251
Uniprot IDs		Q9Y6U3	B3KPP5 P68032
PDB IDs		3FG6 5A1K 5A1M
Enriched GO Terms of Interacting Partners?
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