DPY30 and PRPF3

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DPY30	PRPF3
Description		dpy-30 histone methyltransferase complex regulatory subunit	pre-mRNA processing factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Endosomal Transport Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	mRNA Splicing - Major Pathway
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS		Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Blood protein levels ( 28240269) Chronotype ( 27494321) Low density lipoprotein cholesterol levels ( 30498476) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Platelet count ( 27863252) Plateletcrit ( 27863252)
Interacting Genes		14 interacting genes: ARFGEF1 ASH2L CHMP2B DYDC1 GTF2I H3-4 KMT2C OTX1 PRPF3 PRRC2B PSMD14 SETD1A TMCC2 UBC	31 interacting genes: BRCA1 CASK CCDC85B CDC5L CTNNBL1 DPY30 DVL2 DVL3 FAM9B FRA10AC1 GPRASP2 GTPBP3 MAPRE1 MID2 NAV2 NKAP PCBP1 PHC2 PRPF31 PSMD3 RBM39 SART3 SNIP1 SNRNP200 TRIM39 U2AF2 USP4 WBP4 ZBTB8A ZCCHC10 ZGPAT
Entrez ID		84661	9129
HPRD ID		17434	07389
Ensembl ID		ENSG00000162961	ENSG00000117360
Uniprot IDs		B4DIS3 Q9C005	O43395
PDB IDs		3G36 4RIQ 4RT4 4RTA 6E2H	1X4Q 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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