CUL3 and KLHL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		CUL3	KLHL2
Description		cullin 3	kelch like family member 2
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GO Annotations	Cellular Component	Golgi Membrane Spindle Pole Cell Nucleus Nucleoplasm Cytoplasm Centrosome Polar Microtubule Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Sperm Flagellum Extracellular Exosome Mitotic Spindle	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding	Actin Binding Protein Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Phase Transition	Protein Ubiquitination Post-translational Protein Modification
Pathways		Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 28991256 25056061 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		71 interacting genes: ABTB1 ABTB2 ACLY APP ARHGEF12 BTBD10 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CLK1 COMMD1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 ELOC FOLR1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GPS1 HLA-DMB HSF2 KCTD10 KCTD11 KCTD13 KCTD17 KCTD5 KEAP1 KLHL12 KLHL2 KLHL3 KLHL42 KLHL5 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NEDD8 OLIG2 PDCD6 PDIA2 PEF1 RBBP8 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SPOP SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 UBE2R2 WNT7B ZMAT4	15 interacting genes: ACTC1 BCAM CCDC43 CLK2 CUL3 KLHL12 SDCBP TMA16 TNPO2 TXNDC12 UBE2C UBE2D1 WNK1 WNK4 ZNF114
Entrez ID		8452	11275
HPRD ID		09123	09311
Ensembl ID		ENSG00000036257	ENSG00000109466
Uniprot IDs		A0A024R475 B7Z600 Q13618	B4DFZ5 E9PEX9 O95198
PDB IDs		2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M	2XN4 4CHB
Enriched GO Terms of Interacting Partners?
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