CUL3 and COMMD1

Number of citations of the paper that reports this interaction (PubMedID 21778237)
9

Data Source:
BioGRID (pull down)

		CUL3	COMMD1
Description		cullin 3	copper metabolism domain containing 1
Image
GO Annotations	Cellular Component	Golgi Membrane Spindle Pole Cell Nucleus Nucleoplasm Cytoplasm Centrosome Polar Microtubule Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Sperm Flagellum Extracellular Exosome Mitotic Spindle	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Cul2-RING Ubiquitin Ligase Complex Recycling Endosome
	Molecular Function	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Phase Transition	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface
Pathways		Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
Drugs
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 28991256 25056061 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)
Interacting Genes		71 interacting genes: ABTB1 ABTB2 ACLY APP ARHGEF12 BTBD10 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CLK1 COMMD1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 ELOC FOLR1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GPS1 HLA-DMB HSF2 KCTD10 KCTD11 KCTD13 KCTD17 KCTD5 KEAP1 KLHL12 KLHL2 KLHL3 KLHL42 KLHL5 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NEDD8 OLIG2 PDCD6 PDIA2 PEF1 RBBP8 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SPOP SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 UBE2R2 WNT7B ZMAT4	29 interacting genes: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC KAT2A LIG4 NFKBIA PRKN RELA SLC12A2 SOCS1 SOD1 SPP1 XIAP
Entrez ID		8452	150684
HPRD ID		09123	06253
Ensembl ID		ENSG00000036257	ENSG00000173163
Uniprot IDs		A0A024R475 B7Z600 Q13618	Q8N668
PDB IDs		2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M	2H2M
Enriched GO Terms of Interacting Partners?
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