ASCC2 and POLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ASCC2	POLA2
Description		activating signal cointegrator 1 complex subunit 2	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Activating Signal Cointegrator 1 Complex	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Ubiquitin Binding	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity
	Biological Process	DNA Dealkylation Involved In DNA Repair Regulation Of Transcription, DNA-templated	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		ALKBH3 mediated reversal of alkylation damage	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS		Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Crohn's disease ( 28067908) IgA levels ( 28628107) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Telomere length ( 24478790) Tonsillectomy ( 27941131) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382)	Acne (severe) ( 24927181)
Interacting Genes		40 interacting genes: ASCC3 ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1	41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2
Entrez ID		84164	23649
HPRD ID		16515	10160
Ensembl ID		ENSG00000100325	ENSG00000014138
Uniprot IDs		A0A024R1E1 A0A024R1F9 Q9H1I8	Q14181
PDB IDs		2DI0	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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