POLA2 and TMEM216

		POLA2	TMEM216
Description		DNA polymerase alpha 2, accessory subunit	transmembrane protein 216
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Cytosol Cytoskeleton Cilium Integral Component Of Membrane Ciliary Transition Zone MKS Complex
	Molecular Function	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Non-motile Cilium Assembly
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Anchoring of the basal body to the plasma membrane
Drugs		Dacarbazine
Diseases			Joubert syndrome
GWAS		Acne (severe) ( 24927181)
Interacting Genes		41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2	2 interacting genes: MCM3AP POLA2
Entrez ID		23649	51259
HPRD ID		10160	14439
Ensembl ID		ENSG00000014138	ENSG00000187049
Uniprot IDs		Q14181	J3QT25 Q9P0N5
PDB IDs		2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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