BCAR3 and KPNA1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		BCAR3	KPNA1
Description		BCAR3 adaptor protein, NSP family member	karyopherin subunit alpha 1
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GO Annotations	Cellular Component		Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Host Cell Glutamatergic Synapse
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of DNA Replication Endothelin Receptor Signaling Pathway	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Intracellular Transport Of Virus Postsynapse To Nucleus Signaling Pathway
Pathways			ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)	Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		29 interacting genes: AGR3 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCL5 CST6 DKK3 EPSTI1 ERBB2 ERBB3 ERRFI1 GLCE GREB1 HOXC6 KPNA1 MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP VPS45	39 interacting genes: ANP32A ANP32B ARNT BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LMO4 MDM2 NOSIP NUP54 NUP62 ORC4 PAX5 PKM RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1
Entrez ID		8412	3836
HPRD ID		05268	02819
Ensembl ID		ENSG00000137936	ENSG00000114030
Uniprot IDs		A0A384MTS3 B3KNL6 B3KP06 O75815	B3KXZ2 P52294
PDB IDs		3T6A	2JDQ 3TJ3 4B18
Enriched GO Terms of Interacting Partners?
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