LZTR1 and E2F8

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		LZTR1	E2F8
Description		leucine zipper like transcription regulator 1	E2F transcription factor 8
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Endomembrane System Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Membrane	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytosol RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity Ras GTPase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Placenta Development Sprouting Angiogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Proliferation Negative Regulation Of Cytokinesis Positive Regulation Of DNA Endoreduplication Cell Cycle Comprising Mitosis Without Cytokinesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Trophoblast Giant Cell Differentiation Chorionic Trophoblast Cell Differentiation Hepatocyte Differentiation
Pathways			TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Drugs
Diseases
GWAS
Interacting Genes		54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MRAS MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3	6 interacting genes: APP EWSR1 FHL3 LZTR1 TFCP2 ZDHHC17
Entrez ID		8216	79733
HPRD ID		08992	10981
Ensembl ID		ENSG00000099949	ENSG00000129173
Uniprot IDs		A0A384NL67 Q8N653	A0AVK6
PDB IDs			4YO2
Enriched GO Terms of Interacting Partners?
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