LZTR1 and TBX2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		LZTR1	TBX2
Description		leucine zipper like transcription regulator 1	T-box transcription factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Endomembrane System Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Membrane	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity Ras GTPase Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Heart Looping Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Chamber Development Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Notch Signaling Pathway Central Nervous System Development Muscle Cell Fate Determination Cell Aging Regulation Of Heart Contraction Positive Regulation Of Cell Proliferation Embryonic Heart Tube Development Aorta Morphogenesis Atrioventricular Canal Development Embryonic Digit Morphogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Cardiac Muscle Tissue Development Roof Of Mouth Development Positive Regulation Of Cardiac Muscle Cell Proliferation Pharynx Development Developmental Growth Involved In Morphogenesis Mammary Placode Formation Cellular Senescence Negative Regulation Of Heart Looping Negative Regulation Of Cardiac Chamber Formation
Pathways
Drugs
Diseases
GWAS			Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Chloride levels ( 29403010) Chronic kidney disease ( 20383146) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 29212778) Creatinine levels ( 31015462 20383145) Diastolic blood pressure ( 27841878 27618447 27618448 30487518) Estimated glomerular filtration rate ( 31015462) Height ( 20881960 19893584 18391951) Hypertension ( 27618447 30487518) Mean arterial pressure ( 26390057 27618448 30487518) Potassium levels ( 29403010) Pulse pressure ( 27841878 27618447) Sitting height ratio ( 25865494) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 27841878 28739976 27618447 27618448 30487518)
Interacting Genes		54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MRAS MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3	3 interacting genes: CEBPE LZTR1 NKX2-5
Entrez ID		8216	6909
HPRD ID		08992	02850
Ensembl ID		ENSG00000099949	ENSG00000121068
Uniprot IDs		A0A384NL67 Q8N653	A0A024QZ86 Q13207
PDB IDs
Enriched GO Terms of Interacting Partners?
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