LZTR1 and RUVBL1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		LZTR1	RUVBL1
Description		leucine zipper like transcription regulator 1	RuvB like AAA ATPase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Endomembrane System Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Membrane	Swr1 Complex Nucleus Nucleoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Ribonucleoprotein Complex
	Molecular Function	DNA-binding Transcription Factor Activity Ras GTPase Binding	TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Coactivator Activity Protein Binding ATP Binding ATPase Activity TBP-class Protein Binding 5'-3' DNA Helicase Activity ADP Binding Cadherin Binding ATPase Binding
	Biological Process	Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Cycle Spermatogenesis Histone Acetylation Protein Deubiquitination DNA Duplex Unwinding CENP-A Containing Nucleosome Assembly Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Nucleic Acid-templated Transcription Beta-catenin-TCF Complex Assembly Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways			Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones UCH proteinases Ub-specific processing proteases DNA Damage Recognition in GG-NER Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Gestational age at birth (maternal effect) ( 28877031) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MRAS MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3	20 interacting genes: ACTL6A CEP126 CTNNB1 DKC1 FBL LZTR1 MRGBP MYC NEDD4 OFD1 PLG RUVBL2 STOM SUMO2 TAF9 TBP TERT TK1 YY1 ZNHIT2
Entrez ID		8216	8607
HPRD ID		08992	09143
Ensembl ID		ENSG00000099949	ENSG00000175792
Uniprot IDs		A0A384NL67 Q8N653	A0A384MTR5 B3KRS7 E7ETR0 Q9Y265
PDB IDs			2C9O 2XSZ 5OAF 6FO1 6HTS 6IGM 6QI8 6QI9
Enriched GO Terms of Interacting Partners?
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