CACNB4 and EFHC2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		CACNB4	EFHC2
Description		calcium voltage-gated channel auxiliary subunit beta 4	EF-hand domain containing 2
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse	Microtubule
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity	Calcium Ion Binding Protein Binding
	Biological Process	Chemical Synaptic Transmission Neuromuscular Junction Development Membrane Depolarization Cardiac Conduction Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity	Regulation Of Neuron Projection Development Cellular Response To Leukemia Inhibitory Factor
Pathways		Presynaptic depolarization and calcium channel opening NCAM1 interactions Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs		Nimodipine Spironolactone Verapamil Mibefradil Dronedarone Trimebutine Manidipine
Diseases		Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)	Mean arterial pressure ( 29403010)
Interacting Genes		10 interacting genes: CACNA1A CBX3 EFHC2 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3	37 interacting genes: ARHGEF5 ARMC7 CACNB4 CCDC120 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CYFIP1 DGCR6 EDC3 EFHC1 EGLN3 EMD EXOC8 FAM107A HNRNPLL JAKMIP2 KIF9 LONRF1 MAPK9 NCDN NCK2 NDOR1 NR3C1 PBLD PLOD3 PTK6 RAD51D RUNX1T1 SNRNP25 SPG21 STK16 TRIM42 TSSK3 TUBGCP4
Entrez ID		785	80258
HPRD ID		09057	06540
Ensembl ID		ENSG00000182389	ENSG00000183690
Uniprot IDs		A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 H0Y476 O00305	Q5JST6
PDB IDs		2D46	2Z13 2Z14
Enriched GO Terms of Interacting Partners?
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