PTK6

Description		protein tyrosine kinase 6
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Signal Transduction Positive Regulation Of Neuron Projection Development Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation ERBB2 Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Growth Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization
Drugs		Vandetanib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Hair shape ( 29220522) Prostate cancer ( 23535732)
Interacting Genes		16 interacting genes: APP CCDC33 DOK1 EFHC2 EGFR ERBB3 EXOC5 FCHO1 FGFR1 HIF1A KHDRBS1 KHDRBS2 LINC01139 REL STAP2 WASL
Entrez ID		5753
HPRD ID		03594
Ensembl ID		ENSG00000101213
Uniprot IDs		Q13882
PDB IDs		1RJA 2KGT 5D7V 5DA3 5H2U 6CZ2 6CZ3 6CZ4
Enriched GO Terms of Interacting Partners?
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