DERL1 and MELTF

Number of citations of the paper that reports this interaction (PubMedID 16449195)
42

Data Source:
HPRD (in vivo)

		DERL1	MELTF
Description		derlin 1	melanotransferrin
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Signal Recognition Particle Receptor Complex Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Signal Recognition Particle	Extracellular Region Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protease Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding ATPase Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding	Iron Ion Binding Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Viral Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Protein Binding ERAD Pathway Establishment Of Protein Localization Transmembrane Transport ER-associated Misfolded Protein Catabolic Process	Regulation Of Cell Growth Iron Ion Transport Positive Regulation Of Plasminogen Activation Regulation Of Cell Proliferation Post-translational Protein Modification Cellular Protein Metabolic Process Iron Ion Homeostasis Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins	Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: AMFR APP CFTR HLA-A LMNA MELTF RHO SELENOS TCF25 UBXN6 VCP	5 interacting genes: DERL1 DERL2 DERL3 HPGDS NOTCH2NLA
Entrez ID		79139	4241
HPRD ID		12302	01122
Ensembl ID		ENSG00000136986	ENSG00000163975
Uniprot IDs		A0A024R9G3 E5RGY0 Q9BUN8	P08582 Q53XS6
PDB IDs		5GLF
Enriched GO Terms of Interacting Partners?
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