DERL1 and UBXN6

Number of citations of the paper that reports this interaction (PubMedID 19275885)
11

Data Source:
BioGRID (pull down)

		DERL1	UBXN6
Description		derlin 1	UBX domain protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Signal Recognition Particle Receptor Complex Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Signal Recognition Particle	Nucleus Cytoplasm Lysosomal Membrane Endosome Microtubule Organizing Center Cytosol Extrinsic Component Of Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Protease Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding ATPase Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding	Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Viral Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Protein Binding ERAD Pathway Establishment Of Protein Localization Transmembrane Transport ER-associated Misfolded Protein Catabolic Process	Macroautophagy Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway ERAD Pathway
Pathways		ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Multiple sclerosis ( 31604244)
Interacting Genes		11 interacting genes: AMFR APP CFTR HLA-A LMNA MELTF RHO SELENOS TCF25 UBXN6 VCP	11 interacting genes: APP DERL1 GSK3B MAGEA4 MCL1 NLGN3 SMURF1 TRIM39 UBC UFD1 VCP
Entrez ID		79139	80700
HPRD ID		12302	18253
Ensembl ID		ENSG00000136986	ENSG00000167671
Uniprot IDs		A0A024R9G3 E5RGY0 Q9BUN8	Q9BZV1
PDB IDs		5GLF
Enriched GO Terms of Interacting Partners?
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