DERL1 and TCF25

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DERL1	TCF25
Description		derlin 1	transcription factor 25
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Signal Recognition Particle Receptor Complex Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Signal Recognition Particle	Nucleus
	Molecular Function	Protease Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding ATPase Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding	DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Viral Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Protein Binding ERAD Pathway Establishment Of Protein Localization Transmembrane Transport ER-associated Misfolded Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Development
Pathways		ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Monobrow ( 27182965) Red vs. brown/black hair color ( 30531825) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Rosacea symptom severity ( 29771307)
Interacting Genes		11 interacting genes: AMFR APP CFTR HLA-A LMNA MELTF RHO SELENOS TCF25 UBXN6 VCP	9 interacting genes: APPBP2 DERL1 GPRASP2 KASH5 LRRK1 MAGEA11 NEK2 RPS10 SAT1
Entrez ID		79139	22980
HPRD ID		12302	13830
Ensembl ID		ENSG00000136986	ENSG00000141002
Uniprot IDs		A0A024R9G3 E5RGY0 Q9BUN8	Q9BQ70
PDB IDs		5GLF
Enriched GO Terms of Interacting Partners?
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