MELTF and DERL1

Number of citations of the paper that reports this interaction (PubMedID 16449195)
42

Data Source:
HPRD (in vivo)

		MELTF	DERL1
Description		melanotransferrin	derlin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane Extracellular Exosome	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Signal Recognition Particle Receptor Complex Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Signal Recognition Particle
	Molecular Function	Iron Ion Binding Protein Binding	Protease Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding ATPase Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding
	Biological Process	Regulation Of Cell Growth Iron Ion Transport Positive Regulation Of Plasminogen Activation Regulation Of Cell Proliferation Post-translational Protein Modification Cellular Protein Metabolic Process Iron Ion Homeostasis Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Protein Folding Response To Unfolded Protein Viral Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Protein Binding ERAD Pathway Establishment Of Protein Localization Transmembrane Transport ER-associated Misfolded Protein Catabolic Process
Pathways		Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: DERL1 DERL2 DERL3 HPGDS NOTCH2NLA	11 interacting genes: AMFR APP CFTR HLA-A LMNA MELTF RHO SELENOS TCF25 UBXN6 VCP
Entrez ID		4241	79139
HPRD ID		01122	12302
Ensembl ID		ENSG00000163975	ENSG00000136986
Uniprot IDs		P08582 Q53XS6	A0A024R9G3 E5RGY0 Q9BUN8
PDB IDs			5GLF
Enriched GO Terms of Interacting Partners?
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