MELTF and DERL3

Number of citations of the paper that reports this interaction (PubMedID 16449191)
32

Data Source:
HPRD (in vivo)

		MELTF	DERL3
Description		melanotransferrin	derlin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane Extracellular Exosome	Hrd1p Ubiquitin Ligase ERAD-L Complex Signal Recognition Particle Receptor Complex Integral Component Of Endoplasmic Reticulum Membrane Signal Recognition Particle
	Molecular Function	Iron Ion Binding Protein Binding	Protein Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding
	Biological Process	Regulation Of Cell Growth Iron Ion Transport Positive Regulation Of Plasminogen Activation Regulation Of Cell Proliferation Post-translational Protein Modification Cellular Protein Metabolic Process Iron Ion Homeostasis Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Protein N-linked Glycosylation Via Asparagine Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis
Drugs
Diseases
GWAS			Ejection fraction ( 29403010) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricular internal dimension in systole ( 29403010) S-phenylmercapturic acid levels in smokers ( 26959369)
Interacting Genes		5 interacting genes: DERL1 DERL2 DERL3 HPGDS NOTCH2NLA	2 interacting genes: MELTF SERPINA1
Entrez ID		4241	91319
HPRD ID		01122	13139
Ensembl ID		ENSG00000163975	ENSG00000099958
Uniprot IDs		P08582 Q53XS6	Q96Q80
PDB IDs
Enriched GO Terms of Interacting Partners?
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