RFFL and ESPL1

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		RFFL	ESPL1
Description		ring finger and FYVE like domain containing E3 ubiquitin protein ligase	extra spindle pole bodies like 1, separase
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane	Cell Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle
	Molecular Function	Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Meiotic Chromosome Separation
Pathways		Regulation of TP53 Degradation	Separation of Sister Chromatids
Drugs
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Night sleep phenotypes ( 27126917) QT interval ( 19305408)	Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)
Interacting Genes		21 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7	7 interacting genes: MTNR1B PJA1 RFFL TRIM55 TRIM63 USP21 USP28
Entrez ID		117584	9700
HPRD ID		11489	06825
Ensembl ID		ENSG00000092871	ENSG00000135476
Uniprot IDs		Q8WZ73	Q14674
PDB IDs		1Y02
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?