UBTF and IRS1

Number of citations of the paper that reports this interaction (PubMedID 12554758)
26

Data Source:
HPRD (in vivo)

		UBTF	IRS1
Description		upstream binding transcription factor	insulin receptor substrate 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Intracellular Membrane-bounded Organelle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase I CORE Element Sequence-specific DNA Binding RNA Polymerase I Upstream Control Element Sequence-specific DNA Binding Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Kinase C Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding SH2 Domain Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Regulation Of Transcription By RNA Polymerase I Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway	MAPK Cascade Signal Transduction Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Interleukin-7-mediated Signaling Pathway Glucose Homeostasis Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Kinase B Signaling Cellular Response To Fatty Acid
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Activated NTRK3 signals through PI3K Growth hormone receptor signaling
Drugs			[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Mean corpuscular hemoglobin concentration ( 29403010) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Adiponectin levels ( 22479202) Adiposity ( 21706003) Appendicular lean mass ( 28724990) Birth weight ( 31043758) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage ( 26833246 28270201) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Glucose homeostasis traits ( 25524916) HDL cholesterol ( 24097068 25961943 20686565) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 30598549) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) Lean body mass ( 28724990) Metabolite levels ( 23823483) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Sexual dimorphism in anthropometric traits ( 23754948) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943 20686565) Type 2 diabetes ( 22885922 24509480 29358691 30297969 19734900 31118516 20581827) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference ( 25673412) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		33 interacting genes: AURKA CCNA2 CCND1 CCNE1 CD3EAP CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 EP300 IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2	78 interacting genes: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK3 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 NUMB PASK PDPK1 PELI1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRD PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBC UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID		7343	3667
HPRD ID		02814	00943
Ensembl ID		ENSG00000108312	ENSG00000169047
Uniprot IDs		P17480	P35568
PDB IDs		1K99 1L8Y 1L8Z 2HDZ	1IRS 1K3A 1QQG 2Z8C 5U1M 6BNT
Enriched GO Terms of Interacting Partners?
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