IRS1 and PIK3R3

Number of citations of the paper that reports this interaction (PubMedID 7542745)
48

Data Source:
HPRD (in vivo, in vitro)

		IRS1	PIK3R3
Description		insulin receptor substrate 1	phosphoinositide-3-kinase regulatory subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Intracellular Membrane-bounded Organelle	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Kinase C Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding SH2 Domain Binding Phosphatidylinositol 3-kinase Binding	Phosphotyrosine Residue Binding Protein Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	MAPK Cascade Signal Transduction Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Interleukin-7-mediated Signaling Pathway Glucose Homeostasis Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Kinase B Signaling Cellular Response To Fatty Acid	Positive Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation
Pathways		PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Activated NTRK3 signals through PI3K Growth hormone receptor signaling	GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL
Drugs		[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID	Isoprenaline SF1126
Diseases
GWAS		Adiponectin levels ( 22479202) Adiposity ( 21706003) Appendicular lean mass ( 28724990) Birth weight ( 31043758) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage ( 26833246 28270201) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Glucose homeostasis traits ( 25524916) HDL cholesterol ( 24097068 25961943 20686565) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 30598549) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) Lean body mass ( 28724990) Metabolite levels ( 23823483) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Sexual dimorphism in anthropometric traits ( 23754948) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943 20686565) Type 2 diabetes ( 22885922 24509480 29358691 30297969 19734900 31118516 20581827) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference ( 25673412) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Breast cancer ( 29059683) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483) Sodium levels ( 29403010) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		78 interacting genes: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK3 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 NUMB PASK PDPK1 PELI1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRD PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBC UBTF YWHAB YWHAE YWHAG YWHAZ	81 interacting genes: ABCB6 ABL2 AMBP ANKS1A AUNIP AXL BRK1 BTK CAMK1 CCDC14 CCDC33 CEP126 CEP19 CLNK CRBN CRK DARS1 DCAF8 DRAP1 DSN1 E2F6 EGFR ERBB2 ERBB3 ESR1 FBN3 FER FGB FOXO1 FSD2 FYN GC HROB HSH2D IGF1R INSR IQUB IRS1 IRS2 KARS1 KHDRBS1 KLC2 KLF15 KMT2B L3MBTL3 LNX2 LUC7L2 MBIP MECOM MICAL1 MTF2 NCK1 ORM1 PACRGL PCDHB5 PDGFRB PELO PIK3CA PLB1 PPARA PSME1 QARS1 RB1 RING1 SERF1A SOCS6 SRC STAT3 TEC TERF2 TNNC2 TRIM54 TRMT2A TSPAN2 USP2 VBP1 VCP WRNIP1 ZMAT1 ZNF281 ZNF451
Entrez ID		3667	8503
HPRD ID		00943	05831
Ensembl ID		ENSG00000169047	ENSG00000117461
Uniprot IDs		P35568	B4DXM8 Q68CY7 Q7Z3W2 Q8N381 Q92569
PDB IDs		1IRS 1K3A 1QQG 2Z8C 5U1M 6BNT
Enriched GO Terms of Interacting Partners?
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