UBTF and TCOF1

Number of citations of the paper that reports this interaction (PubMedID 15249688)
91

Data Source:
HPRD (two hybrid, in vivo)

		UBTF	TCOF1
Description		upstream binding transcription factor	treacle ribosome biogenesis factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus	Fibrillar Center Nucleoplasm Nucleolus Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase I CORE Element Sequence-specific DNA Binding RNA Polymerase I Upstream Control Element Sequence-specific DNA Binding Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding	RNA Polymerase I Core Binding RNA Binding Transporter Activity Protein Binding Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Regulation Of Transcription By RNA Polymerase I Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway	Skeletal System Development Regulation Of Translation Neural Crest Formation Neural Crest Cell Development Nucleolar Large RRNA Transcription By RNA Polymerase I
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases			Treacher Collins syndrome
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Mean corpuscular hemoglobin concentration ( 29403010) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		33 interacting genes: AURKA CCNA2 CCND1 CCNE1 CD3EAP CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 EP300 IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2	9 interacting genes: CSNK2A1 CSNK2A2 NOP56 PCNA SPOP SRPK2 TM9SF1 UBC UBTF
Entrez ID		7343	6949
HPRD ID		02814	06026
Ensembl ID		ENSG00000108312	ENSG00000070814
Uniprot IDs		P17480	B4DRA2 E7ETY2 H0Y8Y7 Q13428
PDB IDs		1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?
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