IRS1 and FBXW8

  • Number of citations of the paper that reports this interaction (PubMedID 18498745)
  • 78
  • Data Source:
  • BioGRID (enzymatic study)

IRS1

FBXW8

Description insulin receptor substrate 1 F-box and WD repeat domain containing 8
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Brain structure ( 22504417)
  • Dentate gyrus granule cell layer volume ( 30279459)
  • Dentate gyrus molecular layer volume ( 30279459)
  • HATA volume ( 30279459)
  • Hippocampal subfield CA1 volume ( 30279459)
  • Hippocampal subfield CA3 volume ( 30279459)
  • Hippocampal subfield CA4 volume ( 30279459)
  • Hippocampal tail volume ( 30279459)
  • Marginal zone lymphoma or rheumatoid arthritis ( 31407831)
  • Subiculum volume ( 30279459)
  • Total hippocampal volume ( 30279459)
Interacting Genes 78 interacting genes: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK3 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 NUMB PASK PDPK1 PELI1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRD PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBC UBTF YWHAB YWHAE YWHAG YWHAZ 6 interacting genes: CUL7 IRS1 MYC RBX1 SKP1 UBE2D3
Entrez ID 3667 26259
HPRD ID 00943 16427
Ensembl ID ENSG00000169047 ENSG00000174989
Uniprot IDs P35568 Q8N3Y1
PDB IDs 1IRS 1K3A 1QQG 2Z8C 5U1M 6BNT
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?