UBE3A and TP53BP2

Number of citations of the paper that reports this interaction (PubMedID 29426014)
4

Data Source:
BioGRID (two hybrid)

		UBE3A	TP53BP2
Description		ubiquitin protein ligase E3A	tumor protein p53 binding protein 2
Image
GO Annotations	Cellular Component	Proteasome Complex Cell Nucleus Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	P53 Binding SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process	Cell Cycle Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)	Triptolide cytotoxicity ( 26121980)
Interacting Genes		121 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CTNNB1 DAZAP2 DLG1 E2F1 EAPP EID1 EIF4G1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA4 HSPA5 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK MAGEA12 MAGEA8 MAPK1 MCM6 MCM7 MDM1 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGR PML POLE4 PRAG1 PRDX1 PRKACA PRMT5 PSAP PSMD4 PTCD3 RAD23A RAD23B RARA RMI1 RPS15A RYBP SACS SCAMP1 SCRIB SHBG SIRT6 SMAD9 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446	64 interacting genes: APP ATPAF2 ATXN7 AXIN1 BAIAP2 BCL2 BCL2L1 CCDC92 CRK CSNK2B CWF19L2 DCUN1D1 EEF1A1 GRB2 H2BC4 HIF1AN HNRNPUL1 HYOU1 KIF5A LHX4 LMO4 MAGI1 MAPK8IP2 MRPL20 MTMR14 NAE1 NDC80 NFKB1 NUTM1 OTUB2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CC PRKAB2 PRPF31 PTN RELA RXRB SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TXLNA UBASH3A UBE3A UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YWHAG YWHAQ ZGPAT ZNF26
Entrez ID		7337	7159
HPRD ID		03375	11803
Ensembl ID		ENSG00000114062	ENSG00000143514
Uniprot IDs		Q05086 Q9H2G0	Q13625
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV	1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?